Acquired Factor X Deficiency Associated with Systematized Amyloidosis - A Report

C OAGULATION DEFECTS due to the lack of a single blood clotting factor are almost exclusively congenital and symptoms appear in early life. Acquired defects other than iatrogenic are usually the result of liver dysfunction and in such cases more than one clotting factor is depressed. A case of selective factor X deficiency developing in middle life and associated with extensive amyloidosis has recently been described.’ The present report concerns a middle-aged man who presented with spontaneous bruising of 3 months duration; the abnormal bleeding tendency was due to a pure factor X deficiency, and tile patient was subsequently found to have systematized amyloidosis.